TY - JOUR A2 - Taché, Yvette AU - Moriyasu, Kazuki AU - Ichinose, Takashi AU - Nakahata, Akane AU - Tanaka, Mitsuru AU - Matsui, Toshiro AU - Furuya, Shigeki PY - 2016 DA - 2016/02/11 TI - The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem SP - 6020786 VL - 2016 AB - Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally. SN - 1687-9767 UR - https://doi.org/10.1155/2016/6020786 DO - 10.1155/2016/6020786 JF - International Journal of Peptides PB - Hindawi Publishing Corporation KW - ER -