Research Article
Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
Figure 2
Aβ inhibits hippocampal input into PFC. (a) Representative traces of EPSPs recorded in the PFC and evoked by stimulation of the hippocampal bundle at different frequencies (5–50 Hz) are shown. The EPSPs are represented both under basal conditions (black traces) and after 60 min of continuous application of Aβ (30 nM; gray traces). (b) The amplitude of each EPSP during the different trains is plotted as the absolute value and also as the value normalized to the first EPSP (EPSPn/EPSP1 = Norm. Amplitude). The mean amplitudes of the EPSPs are represented under basal conditions (black dots/lines) and after 60 min of continuous application of Aβ (30 nM; gray dots/lines). (c) The amplitudes of the “compound” EPSPs are represented in the bar graphs quantified as absolute values (upper graph) and also after normalizing to the control (set at 100%; lower graph). Note that Aβ application significantly reduces the synaptic input from the hippocampal fibers into the PFC. Data are presented as mean ± SEM. versus control activity ( slices).
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