Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input

Figure 3

Aβ inhibits PFC-neuron recruitment by hippocampal input stimulation. (a) A representative raster plot shows the activity of PFC neurons and its response to the stimulation of the hippocampal bundle (delivered at second five). Each row represents the activity of a single cell, and each dot represents a cell-activation (i.e., calcium transient). At the bottom, the sum of all the cell-activation instances per bin (bin = 250 ms) is quantified. (b) The graphs represent the mean sums of cell-activation instances per bin for all the frequencies tested. The mean sums are represented both under basal conditions (black lines) and after 60 min of continuous application of Aβ (30 nM; gray lines). (c) Quantification of the number of cell-activation instances in 3 sec (represented by the rectangle) after the different stimulation trains is presented. Note that Aβ application significantly reduces PFC-neuron recruitment when the hippocampal bundle stimulation is applied at high frequencies. Data are presented as mean ± SEM. versus control activity ( slices).

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