gingiv epithelium provid first line defenc from microorgan present dental plaqu onli provid mechan barrier also has activ immun function too gingiv epitheli cell particip innat immun produc rang antimicrobi peptid protect host against oral pathogen these epitheli antimicrobi peptid eaps includ defensin famili cathelicidin ll37 calprotectin adrenomedullin while some constitut express gingiv epitheli cell other induc upon exposur microbi insult like eaps have role determin initi progress oral diseas eaps broad spectrum antimicrobi differ overlap rang activ apart from antimicrobi activ particip sever other crucial role host tissu some instanc defensin chemotact immun cell other calprotectin import wound heal cell prolifer adrenomedullin multifunct peptid has it biolog action wide rang tissu not onli potent vasodil also has sever endocrin effect know detail various bioaction eaps may provid use inform regard util therapeut agent

Mayank Hans

Veenu Madaan Hans

Epithelial Antimicrobial Peptides: Guardian of the Oral Cavity

design bioactiv peptid hispidalin purifi from seed benincasa hispida which medicin plant belong cucurbitacea famili purif achiev use procedur consist extract from potassium phosphat buffer follow fplc hplc step base amino acid residu peptid amphipath basic one net posit charg have isoelectr 81 this peptid without sulphur contain amino acid suggest it extend conform lack doubl bond secondari structur the result obtain from malditof suggest hispidalin molecular mass 57 kda 49 amino acid residu confirm sdspage resolv 60 kda protein band this novel unknown peptid hispidalin show broad potent inhibitori effect against various human bacteri fungal pathogen it growth inhibit signific compar commerci antibacteri antifung drug the hispidalin 40 concentr exhibit 708 dpph free radicalscaveng activ 695 lipid peroxid inhibit thus present studi hispidalin demonstr remark antimicrobi antioxid potenti from seed hispida

Sunayana Sharma

Hirday Narain Verma

Nilesh Kumar Sharma

Cationic Bioactive Peptide from the Seeds of <i>Benincasa hispida</i>

aim recombin human trefoil factor 3 intestin trefoil factor has been suggest partial protect against necrot enterocol nec mechan protect have been defin investig whether protect effect rhtff3 result antiinflammatori respons method the rat were kill day 4 distal ileum harvest morpholog studi immunohistochemistri p65 amount il1 il6 il10 intestin tissu were measur use commerci elisa assay kit result neonat nec il1 il6 il10 were signific higher than normal group normal group il1 il6 were signific decreas amount il10 mark increas compar nec group nec model immunohistochem stain p65 demonstr strong brown color distribut intestin epithelium treatment rhtff3 signific decreas immunoreact p65 nec model conclus intestin inflamm amelior after rhtff3 inject rhtff3 may protect against intestin injuri neonat rat nec model suppress inflammatori respons

Lei Shi

Pang-Hu Zhou

Juan-Li Xi

Hong-Gang Yu

Bing-Hong Zhang

Recombinant Human Trefoil Factor 3 Ameliorates Bowel Injury: Its Anti-Inflammatory Effect on Experimental Necrotizing Enterocolitis

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Table of Contents

Table of Contents: 2014

Epithelial Antimicrobial Peptides: Guardian of the Oral Cavity

Cationic Bioactive Peptide from the Seeds of Benincasa hispida

Recombinant Human Trefoil Factor 3 Ameliorates Bowel Injury: Its Anti-Inflammatory Effect on Experimental Necrotizing Enterocolitis