International Journal of Peptides

Update on Ghrelin


Publishing date
01 Apr 2010
Status
Published
Submission deadline
01 Oct 2009

Lead Editor

1Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima 890-8530, Japan

2Department of Neuroscience, McKnight Brain Institute of University of Florida, P.O. Box 100244 Gainesville, FL 32610-0244, USA

3ADEN Laboratory, Rouen University Medical School, 22 Boulevard Gambetta, 76183 Rouen, France

4Department of Clinical Medicine, University of Rome (Sapienza), Viale dell'Universita 37, 00185 Rome, Italy


Update on Ghrelin

Description

Ghrelin, a 28-amino acid peptide, was identified as the first endogenous ligand for growth hormone secretagogue receptor (GHSR) from the stomach. Ghrelin acts on GHSR to stimulate growth hormone (GH) release, which is distinct from its stimulation by hypothalamic GH-releasing hormone, and features a unique posttranslational modification of O-n–octanoylation at serine 3. The posttranslational modification of octanoylation is the first in peptide discovery history that appears to be essential for GH-releasing ability as well as for acyl ghrelin's regulation of food intake, adiposity, and insulin secretion.

The ghrelin peptides consist of acyl ghrelin, des-acyl ghrelin, and obestatin which are obtained from alternative splicing or from extensive posttranslational modification of preproghrelin. Very recently, the acyl-transferase responsible for ghrelin acylation, ghrelin O-acyltransferase (GOAT), was discovered. Acyl ghrelin, des-acyl ghrelin, and obestatin may be part of a system with multiple effector elements, and form the center of an integrated gut-brain-energy axis modulating appetite, digestive secretion and motility, and metabolism. The investigation of this peptide family makes it possible to penetrate the still undefined pathophysiology of eating and digestive diseases, and opens up new paradigms for drugs that can tackle multiple symptoms in various human disorders.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the role of ghrelin family peptides in basic and clinical medicine. We are particularly interested in manuscripts that report translational research data, and reviews summarizing the results of latest clinical trials are welcomed. The topics to be covered include, but are not limited to:

  • Motilin-ghrelin family in the regulation of GI motility
  • Feeding and body weight regulation by ghrelin peptides
  • Growth hormone and other pituitary and pancreatic hormone secretion
  • Ghrelin peptides and behavior
  • Development of ghrelin agonists and antagonists
  • Application of ghrelin mimetics to anorexia and cachexia
  • Ghrelin antagonism and obesity/metabolic syndrome
  • Ghrelin peptides and immune function

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijpep/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 749401
  • - Review Article

The Avian Proghrelin System

Mark P. Richards | John P. McMurtry
  • Special Issue
  • - Volume 2010
  • - Article ID 493614
  • - Review Article

The Prokinetic Face of Ghrelin

Hanaa S. Sallam | Jiande D. Z. Chen
  • Special Issue
  • - Volume 2010
  • - Article ID 234709
  • - Review Article

Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Susana Sangiao-Alvarellos | Fernando Cordido
  • Special Issue
  • - Volume 2010
  • - Article ID 648045
  • - Review Article

Chronic Renal Failure, Cachexia, and Ghrelin

A. Laviano | Z. Krznaric | ... | F. Rossi Fanelli
  • Special Issue
  • - Volume 2010
  • - Article ID 820794
  • - Review Article

The Roles of Motilin and Ghrelin in Gastrointestinal Motility

Tetsuro Ohno | Erito Mochiki | Hiroyuki Kuwano
  • Special Issue
  • - Volume 2010
  • - Article ID 710852
  • - Review Article

The Effect of Ingested Macronutrients on Postprandial Ghrelin Response: A Critical Review of Existing Literature Data

Chrysi Koliaki | Alexander Kokkinos | ... | Nicholas Katsilambros
  • Special Issue
  • - Volume 2010
  • - Article ID 217267
  • - Review Article

Ghrelin and Metabolic Surgery

Dimitrios J. Pournaras | Carel W. le Roux
  • Special Issue
  • - Volume 2010
  • - Article ID 283549
  • - Review Article

Rikkunshito and Ghrelin

Tomohisa Hattori
  • Special Issue
  • - Volume 2010
  • - Article ID 548457
  • - Review Article

Ghrelin and Functional Dyspepsia

Takashi Akamizu | Hiroshi Iwakura | ... | Kenji Kangawa
  • Special Issue
  • - Volume 2010
  • - Article ID 817457
  • - Review Article

Interactions of Gastrointestinal Peptides: Ghrelin and Its Anorexigenic Antagonists

Anna-Sophia Wisser | Piet Habbel | ... | Peter Kobelt

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