Table of Contents
International Journal of Plant Genomics
Volume 2012, Article ID 680634, 12 pages
Research Article

A Bayesian Framework for Functional Mapping through Joint Modeling of Longitudinal and Time-to-Event Data

1Department of Statistics, Temple University, Philadelphia, PA 19122, USA
2Department of Statistics, The Pennsylvania State University, University Park, PA 16802, USA
3Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA
4Department of Agronomy, Henan Institute of Science and Technology, Xinxiang 453003, China
5National Center for Soybean Improvement, National Key Laboratory of Crop Genetics and Germplasm Enhancement, Soybean Research Institute, Nanjing Agricultural University, Nanjing 210095, China

Received 20 January 2012; Revised 13 March 2012; Accepted 19 March 2012

Academic Editor: Pierre Sourdille

Copyright © 2012 Kiranmoy Das et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The most powerful and comprehensive approach of study in modern biology is to understand the whole process of development and all events of importance to development which occur in the process. As a consequence, joint modeling of developmental processes and events has become one of the most demanding tasks in statistical research. Here, we propose a joint modeling framework for functional mapping of specific quantitative trait loci (QTLs) which controls developmental processes and the timing of development and their causal correlation over time. The joint model contains two submodels, one for a developmental process, known as a longitudinal trait, and the other for a developmental event, known as the time to event, which are connected through a QTL mapping framework. A nonparametric approach is used to model the mean and covariance function of the longitudinal trait while the traditional Cox proportional hazard (PH) model is used to model the event time. The joint model is applied to map QTLs that control whole-plant vegetative biomass growth and time to first flower in soybeans. Results show that this model should be broadly useful for detecting genes controlling physiological and pathological processes and other events of interest in biomedicine.