Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders

Table 1

Differential abundance of CD antigens on Raji and MEC2 cells after treatment with CdA or FdA assessed by flow cytometry.

	Raji + CdA		Raji + FdA		MEC2 + CdA
CD antigen	Fold change^1	𝑃-value^2	Fold change	𝑃-value	Fold change	𝑃-value
CD10	2.4	1×10^−3	No change		No change
CD11a	n.d.		n.d.		1.4	1.6×10^−4
CD20	No change		1.5	6.5×10^−2	1.6	2×10^−6
CD22	0.51	2×10^−6	No change		No change
CD43	n.d.		n.d.		1.5	1×10^−5
CD45	n.d.		n.d.		1.3	1.6×10^−2
CD52	No change		No change		1.6	2.6×10^−3
CD54	1.7	7×10^−4	1.8	1.7×10^−2	1.4	4×10^−3
CD62L	n.d.		n.d.		2.0	3×10^−6
CD80	1.5	1×10^−3	1.5	5×10^−5	1.5	2×10^−5
CD86	1.9	3×10^−5	1.4	1.2×10^−4	2.5	1×10^−4
CD95	1.2	8×10^−5	1.4	1.1×10^−4	1.5	2.8×10^−3

¹Fold change calculated by dividing the median fluorescence intensity for the drug-treated sample by that for the control (Figure 3).
²𝑃-value calculated using the students’ 𝑡-test (𝑛 = 3).
n.d.: CD antigen not detected.