Table of Contents
International Journal of Proteomics
Volume 2011, Article ID 373584, 17 pages
http://dx.doi.org/10.1155/2011/373584
Review Article

The Role of Proteomics in the Diagnosis and Treatment of Women's Cancers: Current Trends in Technology and Future Opportunities

1Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
2Department of Radiation Oncology, Loyola university of Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
3Department of Molecular Pharmacology and Therapeutics, Loyola university of Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
4Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, 240 W Green Street, Athens, GA 30602, USA

Received 11 February 2011; Accepted 7 April 2011

Academic Editor: Melissa Muller

Copyright © 2011 Eun-Kyoung Yim Breuer and Mandi M. Murph. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Technological and scientific innovations over the last decade have greatly contributed to improved diagnostics, predictive models, and prognosis among cancers affecting women. In fact, an explosion of information in these areas has almost assured future generations that outcomes in cancer will continue to improve. Herein we discuss the current status of breast, cervical, and ovarian cancers as it relates to screening, disease diagnosis, and treatment options. Among the differences in these cancers, it is striking that breast cancer has multiple predictive tests based upon tumor biomarkers and sophisticated, individualized options for prescription therapeutics while ovarian cancer lacks these tools. In addition, cervical cancer leads the way in innovative, cancer-preventative vaccines and multiple screening options to prevent disease progression. For each of these malignancies, emerging proteomic technologies based upon mass spectrometry, stable isotope labeling with amino acids, high-throughput ELISA, tissue or protein microarray techniques, and click chemistry in the pursuit of activity-based profiling can pioneer the next generation of discovery. We will discuss six of the latest techniques to understand proteomics in cancer and highlight research utilizing these techniques with the goal of improvement in the management of women's cancers.