Clinical Utility of Serum Autoantibodies Detected by Protein Microarray in Melanoma

Table 4

Adjusted^† associations of glycoproteins with positive nodal status.

Characteristic	Odds ratio	95% CI	P value
ASAH1
500 unit increase	0.272	0.076–0.979	0.0464
>1 SD versus not	Model not estimable
CTSD
500 unit increase	0.867	0.786–0.956	0.0042
>1 SD versus not	0.067	0.006–0.740	0.0275
GRP75
500 unit increase	0.880	0.749–1.034	0.1216
>1 SD versus not	0.644	0.153–2.712	0.5488
GRP94
500 unit increase	1.052	0.976–1.133	0.1871
>1 SD versus not	Model not estimable
LDH
500 unit increase	0.890	0.797–0.993	0.0363
>1 SD versus not	0.135	0.015–1.210	0.0736
Combination: ASAH1, CTSD, and LDH
Any >1 SD versus none	0.045	0.007–0.309	0.0016

^†Adjusted for age, gender, ulceration, and Breslow depth. Due to the very high correlation between mitotic rate and Breslow depth, mitotic rate was omitted from the model.