Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays
Table 1
Clinico-pathological details of patients.
Patient 1
Patient 2
Patient 3
Patient 4
Patient 5
Patient 6
Patient 7
Patient 8
Site of primary tumor
Recto-sigmoid
Caecum
Ascending colon
Sigmoid colon
Recto-sigmoid
Caecum
Ascending colon
Recto-sigmoid
Degree of differentiation
Moderately
Poorly
Poorly
Moderately
Moderately
Poorly
Moderately
Well
Age at diagnosis*
58
71
63
81
50
54
58
65
Gender
F
M
F
M
M
M
F
M
TNM stage of primary tumor
2
3
3
2
3
3
3
2
LM diagnosis**
Met
Synch
Synch
Synch
Synch
Synch
Synch
Synch
Liver involvement***
Solitary <25%
Multiple 25–50%
Multiple >50%
Multiple 25–50%
Three 25–50%
Multiple >50%
Multiple <25%
Four <25%
*Mean age at primary tumor diagnosis: 62.9 ± 10 (mean ± SD).
**Met: Metachronous diagnosis, Synch: Synchronous diagnosis.
***Number of liver metastases (multiple: too many to count), plus percentage of liver involvement.