SELDI-TOF-MS Serum Profiling Reveals Predictors of Cardiac MRI Changes in Marathon Runners

Figure 2

Examples proteins with significant expression changes associated with a significant change in post-race RV EF. (a) shows a relatively abundant protein of m/z 8922.3 in which a low pre-race level was associated with the runners at risk of RV EF reductions whilst (b) shows a lower abundance protein of m/z ratio 17897.5 in which a higher pre-race level predicted risk of RV EF reductions. (c) and (d) show two proteins that exhibited significant alterations at two of the three observation times. (c) shows a less abundant protein (m/z = 17772.3) in which a high pre-race level was associated with at risk runners whilst a lower post-race level was associated with runners who experienced significant RV EF changes. (d) represents a moderately abundant protein of m/z 10418.6 in which significant elevations at the finish line and at the post-race MRI were associated with RV EF reductions. ▲= at risk of RV EF reductions, ■ = no significant changes.