Table of Contents
International Journal of Proteomics
Volume 2012, Article ID 679301, 9 pages
http://dx.doi.org/10.1155/2012/679301
Research Article

SELDI-TOF-MS Serum Profiling Reveals Predictors of Cardiac MRI Changes in Marathon Runners

1Beaumont BioBank, William Beaumont Hospital, Royal Oak, MI 48073, USA
2Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
3Department of Cardiovascular Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA

Received 24 April 2012; Accepted 29 June 2012

Academic Editor: Visith Thongboonkerd

Copyright © 2012 George D. Wilson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Sandvik, J. Erikssen, E. Thaulow, G. Erikssen, R. Mundal, and K. Rodahl, “Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men,” New England Journal of Medicine, vol. 328, no. 8, pp. 533–537, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. P. D. Thompson, B. A. Franklin, G. J. Balady et al., “Exercise and acute cardiovascular events: placing the risks into perspective a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology,” Circulation, vol. 115, no. 17, pp. 2358–2368, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. M. Albert, M. A. Mittleman, C. U. Chae, I. M. Lee, C. H. Hennekens, and J. E. Manson, “Triggering of sudden death from cardiac causes by vigorous exertion,” New England Journal of Medicine, vol. 343, no. 19, pp. 1355–1361, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. B. J. Maron, “The paradox of exercise,” New England Journal of Medicine, vol. 343, no. 19, pp. 1409–1411, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Scott and D. E. R. Warburton, “Mechanisms underpinning exercise-induced changes in left ventricular function,” Medicine and Science in Sports and Exercise, vol. 40, no. 8, pp. 1400–1407, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. T. Jackson, R. Beaglehole, and N. Sharpe, “Sudden death in runners,” New Zealand Medical Journal, vol. 96, no. 730, pp. 289–292, 1983. View at Google Scholar · View at Scopus
  7. D. S. Siscovick, N. S. Weiss, R. H. Fletcher, and T. Lasky, “The incidence of primary cardiac arrest during vigorous exercise,” New England Journal of Medicine, vol. 311, no. 14, pp. 874–877, 1984. View at Google Scholar · View at Scopus
  8. P. D. Thompson, M. P. Stern, and P. Williams, “Death during jogging or running. A study of 18 cases,” Journal of the American Medical Association, vol. 242, no. 12, pp. 1265–1267, 1979. View at Publisher · View at Google Scholar · View at Scopus
  9. B. J. Maron, P. D. Thompson, J. C. Puffer et al., “Cardiovascular preparticipation screening of competitive athletes: a statement for health professionals from the Sudden Death Committee (Clinical cardiology) and Congenital Cardiac Defects Committee (Cardiovascular disease in the young), American Heart Association,” Circulation, vol. 94, no. 4, pp. 850–856, 1996. View at Google Scholar · View at Scopus
  10. B. J. Maron, P. S. Douglas, T. P. Graham, R. A. Nishimura, and P. D. Thompson, “Task Force 1: preparticipation screening and diagnosis of cardiovascular disease in athletes,” Journal of the American College of Cardiology, vol. 45, no. 8, pp. 1322–1326, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. B. J. Maron, P. D. Thompson, M. J. Ackerman et al., “Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 Update: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism: endorsed by the American College of Cardiology foundation,” Circulation, vol. 115, no. 12, pp. 1643–1655, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. B. J. Maron, L. C. Poliac, and W. O. Roberts, “Risk for sudden cardiac death associated with marathon running,” Journal of the American College of Cardiology, vol. 28, no. 2, pp. 428–431, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. W. O. Roberts and B. J. Maron, “Evidence for decreasing occurrence of sudden cardiac death associated with the marathon,” Journal of the American College of Cardiology, vol. 46, no. 7, pp. 1373–1374, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. P. S. Douglas, M. L. O'Toole, W. D. B. Hiller, K. Hackney, and N. Reichek, “Cardiac fatigue after prolonged exercise,” Circulation, vol. 76, no. 6, pp. 1206–1213, 1987. View at Google Scholar · View at Scopus
  15. T. G. Neilan, D. M. Yoerger, P. S. Douglas et al., “Persistent and reversible cardiac dysfunction among amateur marathon runners,” European Heart Journal, vol. 27, no. 9, pp. 1079–1084, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Shave, K. George, G. Whyte, E. Hart, and N. Middleton, “Postexercise changes in left ventricular function: the evidence so far,” Medicine and Science in Sports and Exercise, vol. 40, no. 8, pp. 1393–1399, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. E. B. Fortescue, A. Y. Shin, D. S. Greenes et al., “Cardiac troponin increases among runners in the Boston Marathon,” Annals of Emergency Medicine, vol. 49, no. 2, pp. 137–143, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Scharhag, K. George, R. Shave, A. Urhausen, and W. Kindermann, “Exercise-associated increases in cardiac biomarkers,” Medicine and Science in Sports and Exercise, vol. 40, no. 8, pp. 1408–1415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Tulloh, D. Robinson, A. Patel et al., “Raised troponin T and echocardiographic abnormalities after prolonged strenuous exercise—the Australian ironman triathlon,” British Journal of Sports Medicine, vol. 40, no. 7, pp. 605–609, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Niessner, S. Ziegler, J. Slany, E. Billensteiner, W. Woloszczuk, and G. Geyer, “Increases in plasma levels of atrial and brain natriuretic peptides after running a marathon: are their effects partly counterbalanced by adrenocortical steroids?” European Journal of Endocrinology, vol. 149, no. 6, pp. 555–559, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. A. J. Saenz, E. Lee-Lewandrowski, M. J. Wood et al., “Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon runners before and after the 2005 Boston Marathon,” American Journal of Clinical Pathology, vol. 126, no. 2, pp. 185–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Dursun, E. Monari, A. Cuoghi et al., “Proteomic profiling during atherosclerosis progression using SELDI-TOF-MS: effect of darbepoetin treatment,” Acta Histochemica, vol. 112, no. 5, pp. 432–443, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Hou, M. C. Le Bihan, D. Vega-Avelaira, and G. R. Coulton, “Proteomic changes in hearts of kyphoscoliosis (ky) mutant mice in the absence of structural pathology: implication for the analysis of early human heart disease,” Proteomics, vol. 6, no. 10, pp. 3096–3108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Peronnet, L. Becquart, F. Poirier, M. Cubizolles, G. Choquet-Kastylevsky, and C. Jolivet-Reynaud, “SELDI-TOF MS analysis of the Cardiac Troponin I forms present in plasma from patients with myocardial infarction,” Proteomics, vol. 6, no. 23, pp. 6288–6299, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. J. E. Trivax, B. A. Franklin, J. A. Goldstein et al., “Acute cardiac effects of marathon running,” Journal of Applied Physiology, vol. 108, no. 5, pp. 1148–1153, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. E. P. Diamandis, “Point: Proteomic patterns in biological fluids: do they represent the future of cancer diagnostics?” Clinical Chemistry, vol. 49, no. 8, pp. 1272–1275, 2003. View at Google Scholar
  27. D. C. Nieman, D. A. Henson, L. L. Smith et al., “Cytokine changes after a marathon race,” Journal of Applied Physiology, vol. 91, no. 1, pp. 109–114, 2001. View at Google Scholar · View at Scopus
  28. K. Suzuki, S. Nakaji, M. Yamada et al., “Impact of a competitive marathon race on systemic cytokine and neutrophil responses,” Medicine and Science in Sports and Exercise, vol. 35, no. 2, pp. 348–355, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. I. K. M. Brenner, V. M. Natale, P. Vasiliou, A. I. Moldoveanu, P. N. Shek, and R. J. Shephard, “Impact of three different types of exercise on components of the inflammatory response,” European Journal of Applied Physiology and Occupational Physiology, vol. 80, no. 5, pp. 452–460, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Suzuki, S. Nakaji, M. Yamada, M. Totsuka, K. Sato, and K. Sugawara, “Systemic inflammatory response to exhaustive exercise. Cytokine kinetics,” Exercise immunology review, vol. 8, pp. 6–48, 2002. View at Google Scholar · View at Scopus
  31. H. Bruunsgaard, H. Galbo, J. Halkjaer-Kristensen, T. L. Johansen, D. A. MacLean, and B. K. Pedersen, “Exercise-induced increase in serum inferleukin-6 in humans is related to muscle damage,” Journal of Physiology, vol. 499, no. 3, pp. 833–841, 1997. View at Google Scholar · View at Scopus
  32. G. Camus, J. Poortmans, M. Nys et al., “Mild endotoxaemia and the inflammatory response induced by a marathon race,” Clinical Science, vol. 92, no. 4, pp. 415–422, 1997. View at Google Scholar · View at Scopus
  33. B. K. Pedersen, A. Steensberg, C. Fischer, C. Keller, K. Ostrowski, and P. Schjerling, “Exercise and cytokines with particular focus on muscle-derived il-6,” Exercise Immunology Review, vol. 7, pp. 18–31, 2001. View at Google Scholar · View at Scopus
  34. H. Sprenger, C. Jacobs, M. Nain et al., “Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running,” Clinical Immunology and Immunopathology, vol. 63, no. 2, pp. 188–195, 1992. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Suzuki, M. Totsuka, S. Nakaji et al., “Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage,” Journal of Applied Physiology, vol. 87, no. 4, pp. 1360–1367, 1999. View at Google Scholar · View at Scopus
  36. A. Margeli, K. Skenderi, M. Tsironi et al., “Dramatic elevations of interleukin-6 and acute-phase reactants in athletes participating in the ultradistance foot race spartathlon: severe systemic inflammation and lipid and lipoprotein changes in protracted exercise,” The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, pp. 3914–3918, 2005. View at Publisher · View at Google Scholar
  37. T. C. Poon, “Opportunities and limitations of SELDI-TOF-MS in biomedical research: practical advices,” Expert Review of Proteomics, vol. 4, no. 1, pp. 51–65, 2007. View at Publisher · View at Google Scholar