Table of Contents
International Journal of Proteomics
Volume 2013, Article ID 291415, 13 pages
http://dx.doi.org/10.1155/2013/291415
Research Article

An Internal Standard-Assisted Synthesis and Degradation Proteomic Approach Reveals the Potential Linkage between VPS4B Depletion and Activation of Fatty Acid β-Oxidation in Breast Cancer Cells

1Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
2Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
3Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
4Department of Molecular Pharmacology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA
5Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Received 14 September 2012; Accepted 12 December 2012

Academic Editor: Bomie Han

Copyright © 2013 Zhongping Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Table 1: changes of protein synthesis, degradation and relative abundance induced by VPS4B down-regulation in SKBR3 cells. Supplemental Table 2: proteins with increased relative abundance at 24 hr. Supplemental Table 3: proteins with decreased relative abundance at 24 hr. Supplemental Figure 1(a-f): the dynamic protein profiles of SKBR3_shVPS4B and SKBR3 cells. Supplemental Figure 2: the relationships between protein expression and rates of protein synthesis (a) and protein degradation (b).

  1. Supplementary Materials