An Internal Standard-Assisted Synthesis and Degradation Proteomic Approach Reveals the Potential Linkage between VPS4B Depletion and Activation of Fatty Acid β-Oxidation in Breast Cancer Cells

Table 2

Decreased protein synthesis and increased protein degradation contribute to decreased protein expression in SKBR3_shVPS4B cells.

	Number of proteins*	Percentage (%)
Decreased synthesis only	7	18.4
Increased degradation only	6	15.8
Both	25	65.8

*Number of proteins was calculated from 38 proteins with decreased relative abundance (SKBR3_shVPS4B versus SKBR3 ratio <0.66) at 24 hr.