Table of Contents
International Journal of Proteomics
Volume 2015, Article ID 678527, 9 pages
http://dx.doi.org/10.1155/2015/678527
Research Article

Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells

1Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0315 Oslo, Norway
2Department of Physics, University of Oslo, P.O. Box 1048 Blindern, 0315 Oslo, Norway
3The Biotechnology Centre of Oslo, University of Oslo, P.O. Box 1125 Blindern, 0317 Oslo, Norway
4Department of Biosciences, University of Oslo, P.O. Box 1066 Blindern, 0316 Oslo, Norway

Received 27 June 2015; Revised 7 August 2015; Accepted 18 August 2015

Academic Editor: Michael Hippler

Copyright © 2015 Paula A. Bousquet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1: Proteins exhibiting altered regulation profiles in HeLa cells under hypoxic conditions, as identified by SILAC-based quantitative proteomic analyses.

Supplementary Table 2: Pathway and functional annotation cluster analysis.

Supplementary Figure 1: Workflow of a SILAC experiment.

Supplementary Figure 2: Lactate and glucose concentrations in cells cultivated under normoxic or hypoxic conditions.

Supplementary Figure 3: Pie charts of PANTHER biological processes and molecular functions.

Supplementary Figure 4: Western blot analysis of selected regulated proteins.

  1. Supplementary Material