Research Article

SILAC-Based Quantitative Proteomic Analysis of Diffuse Large B-Cell Lymphoma Patients

Table 2

Annotation clusters according to DAVID using an EASE score of 0.01.

NameNumber of proteins value

Annotation cluster 1Enrichment score 3.07

Actin binding80.00012
Cell projection70.00032
ARP2/3 protein complex30.00072
Cytoskeletal protein binding90.0072

Annotation cluster 2Enrichment score 2.96

Mitochondrial inner membrane40.000079
Hydrogen ion transmembrane transporter activity60.00015
Inorganic cation transmembrane transporter activity70.0002
Respiratory chain50.00029
Monovalent inorganic cation transmembrane transporter activity60.00029
Membrane-associated complex40.00039
Cytochrome-c oxidase activity40.00051
Oxidoreductase activity, acting on heme group of donors, oxygen as acceptor40.00051
Heme-copper terminal oxidase activity40.00051
Oxidative phosphorylation40.00051
Transmembrane protein110.00058
Electron transfer40.0015
Generation of precursor metabolites and energy80.0019
Huntington’s disease70.0029
Oxidoreductase90.0036
Mitochondrion110.0039

Annotation cluster 3Enrichment score 2.81

Antigen-processing and presentation of peptide antigen40.0005
MHC class I30.00087
Heterodimer50.0012
Antigen processing and presentation of peptide antigen via MHC class I30.004

Annotation cluster 4Enrichment score 2.78

Vesicle coat50.000073
Retrograde vesicle-mediated transport, Golgi to ER40.00021
Cytoplasmic membrane-bounded vesicle120.00038
Membrane-bounded vesicle120.0005
Membrane coat50.00053
Golgi vesicle budding30.0014
Cytoplasmic vesicle120.0014
Melanosome50.0019
Pigment granule50.0019
Membrane budding30.0036
Golgi membrane60.005
Golgi apparatus130.0051
Membrane organization80.0055

Annotation cluster 5Enrichment score 2.45

Nucleolus120.0027
Intracellular organelle lumen210.003
Organelle lumen210.004
Membrane-enclosed lumen210.005