Sequencing of the human genome has greatly impacted the proteomics-based analysis of disease by providing a framework for understanding the proteome of diseased cells, tissues, and biological fluids. There is much interest in applying proteomics technologies to discover processes at the protein level that are involved in various diseases, to uncover new biomarkers that correlate with the early diagnosis of diseases and to accelerate the development of new therapeutic targets. New proteomics technologies are being developed in order to facilitate both the high-throughput and high-sensitivity requirements of disease-related applications of proteomics. These innovative technologies have greatly enhanced our ability to separate and characterize complex protein mixtures. They have also aided our ability to identify proteins with greater sensitivity, thereby providing the groundwork for future scientific breakthroughs and possibly providing the framework for the development of personalized disease therapy.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand disease subtypes at the protein level, the development of protein-based biomarkers for the early detection of disease, the development of treatment modalities based upon disease-specific protein biomarker signatures, and the protein- biomarker-based evaluation of therapeutic efficacy. We are interested in articles that explore aspects of protein-based biomarkers in humans and also in animal models of disease. Potential topics include, but are not limited to:

• Protein-based signatures of disease subtypes, with emphasis on the expression of different protein biomarkers reflective of a given disease subtype
• Protein-based biomarkers for the early detection of diseases, including potential disease-specific posttranslational modifications of proteins
• Latest technologies for the elucidation of protein signatures of disease, including autoantibodies
• Role of protein biomarkers in the process of drug development
• Role of protein biomarkers in the evaluation of therapeutic efficacy
• Role of protein biomarkers in predicting and monitoring side effects of therapeutic intervention

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