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International Journal of Polymer Science
Volume 2013, Article ID 476748, 10 pages
http://dx.doi.org/10.1155/2013/476748
Research Article

Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering

1Institute of Macromolecular Compounds RAS Bolshoy Prospect 31, Saint Petersburg 199004, Russia
2Chemistry Department, Saint-Petersburg State University Peterhof, Universitetskii Prospect 26, Saint Petersburg 198504, Russia

Received 16 April 2013; Accepted 20 August 2013

Academic Editor: Marek Cypryk

Copyright © 2013 V. A. Korzhikov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The optimization of enzyme-mediated polymerization of pentadecalactone (PDL) was performed to obtain macromolecular products suitable for generation of 3D cell supports (scaffolds) for bone tissue engineering. Such parameters as temperature, monomer/enzyme ratio, and monomer concentration were studied. The maximum molecular weight of synthesized polymers was about 90,000. Methods allowing the introduction of reactive double bonds into polypentadecalactone (polyPDL) structure were developed. The macroporous matrices were obtained by modification of thermoinduced phase separation method.