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International Journal of Polymer Science
Volume 2014, Article ID 736898, 8 pages
http://dx.doi.org/10.1155/2014/736898
Research Article

Electrical Signal Guided Ibuprofen Release from Electrodeposited Chitosan Hydrogel

School of Resource and Environmental Science and Hubei Biomass-Resource, Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China

Received 5 March 2014; Accepted 2 August 2014; Published 19 August 2014

Academic Editor: Qijin Zhang

Copyright © 2014 Youyu Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Electrical signal guided drug release from conductive surface provides a simple and straightforward way for advanced drug delivery. In this study, we investigated the ibuprofen release from electrodeposited chitosan hydrogel by applying electrical signals. Specifically, chitosan hydrogel was electrodeposited on titanium plate and used as a matrix for ibuprofen load and release. The release of ibuprofen from the chitosan hydrogel on titanium plate was pH sensitive. By applying a positive or negative electrical potential, the release rate of ibuprofen from the electrodeposited chitosan can be facilely controlled. Thus, coupling chitosan electrodeposition and electrical signal control spurs new possibilities for biopolymeric coating and drug elution on conductive implants.