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International Journal of Polymer Science
Volume 2015 (2015), Article ID 187961, 15 pages
http://dx.doi.org/10.1155/2015/187961
Research Article

Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

1Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan
2Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22010, Pakistan

Received 13 February 2015; Revised 19 April 2015; Accepted 19 May 2015

Academic Editor: Xingxun Liu

Copyright © 2015 Syed Majid Hanif Bukhari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Devi and A. Narzary, “Release dynamics of brufen from a drug-loaded polymer hydrogel containing polyvinyl alcohol, 2-acrylamide-2-methylpropane sulfonic acid and acrylamide,” International Journal of Polymeric Materials, vol. 61, no. 11, pp. 821–833, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. T. R. Hoare and D. S. Kohane, “Hydrogels in drug delivery: progress and challenges,” Polymer, vol. 49, no. 8, pp. 1993–2007, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. W. E. Hennink and C. F. Van Nostrum, “Novel crosslinking methods to design hydrogels,” Advanced Drug Delivery Reviews, vol. 64, pp. 223–236, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. N. A. Peppas, J. Z. Hilt, A. Khademhosseini, and R. Langer, “Hydrogels in biology and medicine: from molecular principles to bionanotechnology,” Advanced Materials, vol. 18, no. 11, pp. 1345–1360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. G. Sullad, L. S. Manjeshwar, and T. M. Aminabhavi, “Novel pH-sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid-graft-guar gum matrixes for isoniazid delivery,” Industrial and Engineering Chemistry Research, vol. 49, no. 16, pp. 7323–7329, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Çaykara and E. Turan, “Effect of the amount and type of the crosslinker on the swelling behavior of temperature-sensitive poly(N-tert-butylacrylamide-co-acrylamide) hydrogels,” Colloid and Polymer Science, vol. 284, no. 9, pp. 1038–1048, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Hanif, N. M. Ranjha, M. H. Shoaib et al., “Preparation, characterization and release of verapmil hydrochloride from polycaprolactone/acrylic acid (PCL/AA) hydrogels,” Pakistan Journal of Pharmaceutical Sciences, vol. 24, no. 4, pp. 503–511, 2011. View at Google Scholar · View at Scopus
  8. B. S. Kaith, R. Jindal, and G. S. Kapur, “Enzyme-based green approach for the synthesis of gum tragacanth and acrylic acid cross-linked hydrogel: its utilization in controlled fertilizer release and enhancement of water-holding capacity of soil,” Iranian Polymer Journal, vol. 22, no. 8, pp. 561–570, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. L. Lo, C. Y. Hsu, and H. R. Lin, “PH-and thermo-sensitive pluronic/poly(acrylic acid) in situ hydrogels for sustained release of an anticancer drug,” Journal of Drug Targeting, vol. 21, no. 1, pp. 54–66, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. A. K. Bajpai and S. Kankane, “Evaluation of water sorption property and in vitro blood compatibility of poly(2-hydroxyethyl methacrylate) (PHEMA) based semi interpenetrating polymer networks (IPNs),” Journal of Materials Science: Materials in Medicine, vol. 19, no. 5, pp. 1921–1933, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Kheirandish and E. Jabbari, “Effect of surface polarity on wettability and friction coefficient of silicone rubber/poly(acrylic acid) hydrogel composite,” Colloid and Polymer Science, vol. 284, no. 12, pp. 1411–1417, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. S. J. You, W. S. Ahn, H. S. Jang et al., “Preparation and characterization of gelatin-poly(vinyl alcohol) hydrogels for three-dimensional cell culture,” Journal of Industrial and Engineering Chemistry, vol. 13, no. 1, pp. 116–120, 2007. View at Google Scholar · View at Scopus
  13. K. Pal, A. K. Banthia, and D. K. Majumdar, “Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications,” AAPS PharmSciTech, vol. 8, no. 1, article no. 21, pp. E142–E146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. K. Mishra, A. B. Majeed, and A. K. Banthia, “Development and characterization of pectin/gelatinhydrogel membranes for wound dressing,” International Journal of Plastics Technology, vol. 15, no. 1, pp. 82–95, 2011. View at Google Scholar
  15. A. K. Bajpai and M. Sharma, “Preparation and characterization of binary grafted polymeric blends of polyvinyl alcohol and gelatin and evaluation of their water uptake potential,” Journal of Macromolecular Science, vol. 42, no. 5, pp. 663–682, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. Q. Tang, J. Wu, J. Lin, S. Fan, and D. Hu, “A multifunctional poly(acrylic acid)/gelatin hydrogel,” Journal of Materials Research, vol. 24, no. 5, pp. 1653–1661, 2009. View at Publisher · View at Google Scholar
  17. A. Bigi, G. Cojazzi, S. Panzavolta, K. Rubini, and N. Roveri, “Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking,” Biomaterials, vol. 22, no. 8, pp. 763–768, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. M. S. Raghu, K. Basavaiah, P. J. Ramesh, S. A. M. Abdulrahman, and K. B. Vinay, “Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies,” Journal of Applied Spectroscopy, vol. 79, no. 1, pp. 131–138, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. N. M. Ranjha, G. Ayub, S. Naseem, and M. T. Ansari, “Preparation and characterization of hybrid pH-sensitive hydrogels of chitosan-co-acrylic acid for controlled release of verapamil,” Journal of Materials Science: Materials in Medicine, vol. 21, no. 10, pp. 2805–2816, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. N. M. Ranjha, J. Mudassir, and Z. Z. Sheikh, “Synthesis and characterization of pH-Sensitive pectin/Acrylic acid hydrogels for verapamil release study,” Iranian Polymer Journal, vol. 20, no. 2, pp. 147–159, 2011. View at Google Scholar · View at Scopus
  21. N. M. Ranjha, J. Mudassir, and S. Majeed, “Synthesis and characterization of polycaprolactone/acrylic acid (PCL/AA) hydrogel for controlled drug delivery,” Bulletin of Materials Science, vol. 34, no. 7, pp. 1537–1547, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Khan and N. M. Ranjha, “Effect of degree of cross-linking on swelling and on drug release of low viscous chitosan/poly(vinyl alcohol) hydrogels,” Polymer Bulletin, vol. 71, no. 8, pp. 2133–2158, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Shah, N. M. Ranjha, and Z. Javaid, “Development and evaluation of pH-dependent interpenetrating network of acrylic acid/polyvinyl alcohol,” Iranian Polymer Journal, vol. 22, no. 11, pp. 811–820, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Mudassir and N. M. Ranjha, “Dynamic and equilibrium swelling studies: crosslinked pH sensitive methyl methacrylate-co-itaconic acid (MMA-co-IA) hydrogels,” Journal of Polymer Research, vol. 15, no. 3, pp. 195–203, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. S. Fodor, G. Kali, and B. Iván, “Poly(N-vinylimidazole)-l-poly(tetrahydrofuran) amphiphilic conetworks and gels: synthesis, characterization, thermal and swelling behavior,” Macromolecules, vol. 44, no. 11, pp. 4496–4502, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. N. M. Ranjha and J. Mudassir, “Swelling and aspirin release study: cross-linked pH-sensitive vinyl acetate-co-acrylic acid (VAC-co-AA) hydrogels,” Drug Development and Industrial Pharmacy, vol. 34, no. 5, pp. 512–521, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Hussain, N. M. Ranjha, and Y. Shahzad, “Swelling and controlled release of tramadol hydrochloride from a pH-sensitive hydrogel,” Designed Monomers and Polymers, vol. 14, no. 3, pp. 233–249, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Wang, D. J. T. Hill, F. Rasoul, and A. K. Whittaker, “A study of the swelling and model protein release behaviours of radiation-formed poly(N-vinyl 2-pyrrolidone-co-acrylic acid) hydrogels,” Radiation Physics and Chemistry, vol. 80, no. 2, pp. 207–212, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Basak, B. Adhikari, and A. K. Sen, “Surface cross-linked poly (Vinyl alcohol) hydrogel for colon targeted drug release,” Polymer—Plastics Technology and Engineering, vol. 50, no. 13, pp. 1357–1361, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Najib and M. S. Suleiman, “The kinetics of drug release from ethylcellulose solid dispersions,” Drug Development and Industrial Pharmacy, vol. 11, no. 12, pp. 2169–2181, 1985. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Hosseinzadeh, “Novel interpenetrating polymer network based on chitosan for the controlled release of cisplatin,” Journal of Basic and Applied Scientific Research, vol. 2, no. 3, pp. 2200–2203, 2012. View at Google Scholar
  32. H. Byun, B. Hong, S. Y. Nam et al., “Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid),” Macromolecular Research, vol. 16, no. 3, pp. 189–193, 2008. View at Publisher · View at Google Scholar
  33. B. Singh, G. S. Chauhan, D. K. Sharma, and N. Chauhan, “The release dynamics of salicylic acid and tetracycline hydrochloride from the psyllium and polyacrylamide based hydrogels (II),” Carbohydrate Polymers, vol. 67, no. 4, pp. 559–565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. S. A. Dergunov, I. K. Nam, G. A. Mun, Z. S. Nurkeeva, and E. M. Shaikhutdinov, “Radiation synthesis and characterization of stimuli-sensitive chitosan-polyvinyl pyrrolidone hydrogels,” Radiation Physics and Chemistry, vol. 72, no. 5, pp. 619–623, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Yin, L. Fei, F. Cui, C. Tang, and C. Yin, “Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks,” Biomaterials, vol. 28, no. 6, pp. 1258–1266, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Pourjavadi and S. Barzegar, “Smart pectin-based superabsorbent hydrogel as a matrix for ibuprofen as an oral non-steroidal antiinflammatory drug delivery,” Starch, vol. 61, no. 3-4, pp. 173–187, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Liu, W. Wang, and A. Wang, “Synthesis, characterization, and swelling behaviors of chitosan-g-poly(acrylic acid)/poly(vinyl alcohol) semi-IPN superabsorbent hydrogels,” Polymers for Advanced Technologies, vol. 22, no. 5, pp. 627–634, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Huang, H. Yu, and C. Xiao, “pH-sensitive cationic guar gum/poly (acrylic acid) polyelectrolyte hydrogels: swelling and in vitro drug release,” Carbohydrate Polymers, vol. 69, no. 4, pp. 774–783, 2007. View at Publisher · View at Google Scholar · View at Scopus