Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers

Scheme 1

Ring-opening copolymerization of 2,3,4-tri-O-benzylated 1,6-anhydroglucose (LGTBE) 1 and 3-O-octadecyl 2,4-di-O-benzyl 1,6-anhydroglucose (LGDBE3-18) 2 into sulfated 3-O-octadecyl(16)-α-D-glucopyranan 5 after debenzylation of 3 and subsequent sulfation of 4.