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International Journal of Polymer Science
Volume 2015 (2015), Article ID 902365, 8 pages
http://dx.doi.org/10.1155/2015/902365
Research Article

Electrospun Fibers of Enteric Polymer for Controlled Drug Delivery

1Instituto de Pesquisa em Ciência dos Materiais, Universidade Federal do Vale do São Francisco, 48920-310 Juazeiro, BA, Brazil
2Programa de Pós-Graduação em Engenharia Industrial, Escola Politécnica, Universidade Federal da Bahia, 40210-630 Salvador, BA, Brazil

Received 24 November 2014; Revised 19 December 2014; Accepted 3 March 2015

Academic Editor: Pornsak Sriamornsak

Copyright © 2015 Fábia F. P. da Costa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The production of electrospun fibers of enteric polymer for controlled delivery of drugs represents a simple and low cost procedure with promising advantages relative to the longer therapeutic window provided by cylindrical geometry in association with intrinsic properties of pH-dependent drug carriers. In this work, we have explored the incorporation of additives (block copolymers of poly(ethylene)-b-poly(ethylene oxide)) into matrix of Eudragit L-100 and the effective action of hybrid composites on delivery of nifedipine, providing improvement in the overall process of controlled release of loaded drug.