Research Article
Nanosuspension: An Emerging Trend for Bioavailability Enhancement of Etodolac
Table 3
Dissolution parameters of ET nanosuspensions prepared by pH shift or antisolvent method in both distilled water and phosphate buffer (PB) pH 6.8.
| Formula code | pH shift method | | Antisolvent method | Distilled water | PB pH 6.8 | Formula code | Distilled water | PB pH 6.8 | | | | | | | | | |
| F1 | 17.80 | 9.27 | 82.40 | 13.73 | F1 | 17.8 | 9.27 | 82.40 | 13.73 | F3 | 78.90 | 15.29 | 98.08 | 32.70 | F11 | 24.30 | 4.66 | 99.00 | 49.50 | F4 | 79.90 | 26.63 | 77.65 | 17.26 | F12 | 84.50 | 15.09 | 99.00 | 49.50 | F5 | 39.10 | 7.56 | 96.65 | 46.33 | F13 | 97.50 | 49.75 | 96.00 | 32.32 | F6 | 75.23 | 12.71 | 83.70 | 15.67 | F14 | 57.60 | 9.80 | 93.60 | 20.80 | F7 | 82.70 | 14.06 | 90.05 | 15.47 | F15 | 93.40 | 46.70 | 91.60 | 48.21 | F8 | 52.00 | 9.24 | 67.90 | 11.85 | F16 | 95.20 | 47.60 | 91.20 | 31.93 | F9 | 77.65 | 12.94 | 97.60 | 32.50 | F17 | 95.40 | 48.28 | 83.40 | 28.37 | F10 | 96.00 | 48.00 | 98.08 | 31.80 | F18 | 107.7 | 4.39 | 90.50 | 31.16 |
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F1 = Crude drug. DR10 min: % drug released after 10 min; DE: % dissolution efficiency after 10 min.
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