Research Article

Nanosuspension: An Emerging Trend for Bioavailability Enhancement of Etodolac

Table 3

Dissolution parameters of ET nanosuspensions prepared by pH shift or antisolvent method in both distilled water and phosphate buffer (PB) pH 6.8.

Formula codepH shift methodAntisolvent method
Distilled waterPB pH 6.8Formula codeDistilled waterPB pH 6.8

F1 17.809.2782.4013.73F117.89.2782.4013.73
F3 78.9015.2998.0832.70F1124.30 4.6699.0049.50
F479.9026.6377.6517.26F1284.5015.0999.0049.50
F539.10 7.5696.6546.33F1397.5049.7596.0032.32
F675.2312.7183.7015.67F1457.60 9.8093.6020.80
F782.7014.0690.0515.47F1593.4046.7091.6048.21
F852.00 9.2467.9011.85F1695.2047.6091.2031.93
F977.6512.9497.6032.50F1795.4048.2883.4028.37
F1096.0048.0098.0831.80F18107.7 4.3990.5031.16

F1 = Crude drug.
DR10 min: % drug released after 10 min; DE: % dissolution efficiency after 10 min.