Nanosuspension: An Emerging Trend for Bioavailability Enhancement of Etodolac

Table 4

Pharmacokinetic parameters after oral administration of ET formulations.

Pharmacokinetic parameter	Formulation A; (Mean ± SD)^*	Formulation B; (Mean ± SD)^*
(μg⋅h⋅mL^−1)	36.5 ± 2.27	55.07 ± 9.88 (63.417)
(μg⋅h⋅mL^−1)	38.16 ± 2.26	58.20 ± 9.55
μg⋅mL^−1	2.38 ± 0.30	3.78 ± 0.13
(h)	4.0	3.0
(h)	10.93 ± 0.62	11.60 ± 0.97
(h)	0.063 ± 0.004	0.06 ± 0.01
MRT (h)	11.51 ± 0.77	12.92 ± 0.27
% absorbed in 1 h	7.79 ± 0.26	21.20 ± 0.69
Clearance rate (mg/mL)	132	86

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