Effect of Alginate Lyase on Biofilm-Grown Helicobacter pylori Probed by Atomic Force Microscopy
Representative zoom AFM images ( μm) of H. pylori biofilm are shown before treatment (a–c) and after treatment with AlgL (e–g). Height images (a and d) show different cells from each experimental condition and the presence of fractures in biofilm generated by AlgL treatment (d). Deflection and lateral images (b, e, c and f) reveal more details in biofilm texture. In Figures (g and h) the roughness distribution and Gaussian fit (black lines) are shown for each sample. The distributions were obtained following the procedure described in Section 2. Distributions of the friction forces between AFM tip and three different surfaces: clean glass, biofilm, and biofilm treated with 30 U/mL AlgL (i).
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