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International Journal of Polymer Science
Volume 2016, Article ID 1584046, 11 pages
Research Article

Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications

1Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City (VNU-HCMC), HCMC 700000, Vietnam
2The Center for Molecular Biomedicine, University of Medicine and Pharmacy, HCMC 700000, Vietnam
3Institute of Applied Materials Science, Vietnam Academy of Science and Technology, HCMC 700000, Vietnam
4Research Laboratories of Saigon Hi-Tech Park, HCMC 700000, Vietnam

Received 6 June 2016; Accepted 15 September 2016

Academic Editor: Karol Kyzioł

Copyright © 2016 Nguyen Thi Hiep et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to fabricate chitosan/poly(vinyl alcohol)/Ag nanoparticles (CPA) gels with microwave-assistance for skin applications. Microwave irradiation was employed to reduce silver ions to silver nanoparticles and to crosslink chitosan (CS) with polyvinyl alcohol (PVA). The presence of silver nanoparticles in CPA gels matrix was examined using UV-Vis spectroscopy, transmission electron microscopy, and X-ray diffraction. The interaction of CS and PVA was analysed by Fourier transform infrared spectroscopy. The release of silver ions was determined by atomic absorption spectrometry. The antimicrobial properties of CPA gels against P. aeruginosa and S. aureus were investigated using agar diffusion method. Finally, the biocompatibility and wound-healing ability of the gels were studied using fibroblast cells (in vitro) and mice models (in vivo). In conclusion, the results showed that CPA gels were successfully fabricated using microwave irradiation method. These gels can be applied to heal an open wound thanks to their antibacterial activity and biocompatibility.