Figure 3: Potentiometric electronic tongue plot showing taste clusters of reference solution (0.0001 M Ca(NO3)2, 0.0001 M NaCl) (REF), pure ranitidine hydrochloride (RNT), microspheres placebo (ALG), and microspheres prepared with using 1% and 2% ALG solution (RNT + ALG 1% and RNT + ALG 2%, resp.). Samples were placed in 100 mL of deionized water; measurement time was 7 min with signal acquisition every 5 s. The data were processed using Principal Component Analysis (PCA) with autoscaling (author’s original unpublished data).