Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying

Figure 5

The effect of microspheres placebo (placebo), microspheres formulation F6 (F6), and metformin hydrochloride (MF) in an amount corresponding to its loading in microspheres formulation F6 (2.27 mg, 3.78 mg, and 7.56 mg, resp.) on the in vitro -amylase inhibition (a), and representative images of reactive mixture: without α-amylase , with α-amylase , with acarbose , with microspheres placebo , with microspheres formulation F6 , and with 7.56 mg of pure metformin hydrochloride (in an amount corresponding to its loading in microspheres formulation F6) (b), .

(a)

(b)