Research Article
Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying
Table 1
Characteristics of MF loaded ALG microspheres (formulations F1–F9).
| | Formulation | Drug : polymer ratio | Zeta potential (mV) | Production yield (%) | Encapsulation efficiency (%) | Percent loading (%) | Mean diameter (µm) | Porosity (%) |
| | 1% ALG solution | | F1 | 1 : 2 | −5.3 ± 0.3 | 57.1 ± 1.6 | 119.8 ± 2.1 | 39.9 ± 1.7 | 3.5 ± 0.8 | 73.39 ± 2.3 | | F2 | 1 : 1 | −3.4 ± 0.4 | 86.1 ± 2.4 | 111.9 ± 2.7 | 55.6 ± 3.4 | 3.4 ± 1.1 | 67.02 ± 4.2 | | F3 | 2 : 1 | −1.4 ± 0.9 | 85.9 ± 1.4 | 109.4 ± 3.2 | 72.9 ± 1.6 | 1.7 ± 0.9 | 60.71 ± 3.5 |
| | 2% ALG solution | | F4 | 1 : 2 | −5.8 ± 2.3 | 61.8 ± 1.5 | 115.4 ± 1.9 | 38.4 ± 2.2 | 5.7 ± 1.1 | 75.04 ± 2.5 | | F5 | 1 : 1 | −4.2 ± 0.9 | 68.0 ± 1.3 | 103.1 ± 2.1 | 51.5 ± 3.6 | 3.6 ± 0.5 | 65.55 ± 2.4 | | F6 | 2 : 1 | −1.3 ± 0.7 | 61.7 ± 2.1 | 113.4 ± 2.3 | 75.6 ± 1.5 | 3.0 ± 1.6 | 61.81 ± 3.7 |
| | 3% ALG solution | | F7 | 1 : 2 | −7.7 ± 3.8 | 68.9 ± 1.1 | 111.9 ± 2.6 | 37.3 ± 3.9 | 4.0 ± 0.8 | 72.97 ± 3.5 | | F8 | 1 : 1 | −3.7 ± 1.5 | 58.9 ± 1.4 | 111.1 ± 2.9 | 55.7 ± 3.9 | 2.5 ± 1.3 | 60.88 ± 2.9 | | F9 | 2 : 1 | −1.8 ± 1.1 | 45.0 ± 2.1 | 110.4 ± 3.1 | 73.6 ± 7.5 | 1.6 ± 0.4 | 59.70 ± 2.5 |
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