Research Article

Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying

Table 2

Mucoadhesive properties of microspheres placebo (F0) and microspheres formulations F1–F9.

FormulationType of adhesive layer
GelatinMucinPorcine stomach mucosa
  [N]  [µJ]  [N]  [µJ]  [N]  [µJ]

F00.9 ± 0.3362.9 ± 1.81.1 ± 3.7583.4 ± 1.51.3 ± 1.3779.5 ± 2.4
F10.5 ± 0.2237.5 ± 1.00.5 ± 0.2275.1 ± 1.60.7 ± 0.1428.0 ± 2.6
F20.5 ± 0.2203.0 ± 0.60.5 ± 0.3207.2 ± 0.50.7 ± 0.2360.9 ± 1.3
F30.4 ± 0.3179.5 ± 0.40.5 ± 0.4179.5 ± 0.10.7 ± 0.1272.3 ± 0.5
F40.5 ± 0.2392.8 ± 2.10.6 ± 0.2410.0 ± 2.80.8 ± 0.2681.6 ± 3.9
F50.4 ± 0.2264.0 ± 0.30.6 ± 0.3367.7 ± 1.50.7 ± 0.3560.3 ± 4.1
F60.5 ± 0.2238.3 ± 0.50.6 ± 0.3342.3 ± 2.90.6 ± 0.2467.5 ± 1.7
F70.5 ± 0.3319.4 ± 1.50.6 ± 0.2501.0 ± 3.10.9 ± 0.1768.2 ± 5.4
F80.5 ± 0.2303.7 ± 1.30.7 ± 0.4489.6 ± 3.80.8 ± 0.2692.1 ± 4.6
F90.4 ± 0.1234.2 ± 0.60.7 ± 0.3441.8 ± 2.30.6 ± 0.3657.7 ± 4.3

Maximum detachment force and work of adhesion.