Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying

Table 3

Models of MF release from microspheres formulations F1–F9.

Formulation	Zero-order kinetics		First-order kinetics		Highuchi model		Korsmeyer-Peppas model			Hixson-Crowell model
	F1	0.92	1.67	0.97	0.17	0.98	22.98	0.94	0.31	0.08	0.96	0.18
F2	0.86	1.68	0.98	0.55	0.95	29.37	0.88	0.34	0.08	0.94	0.58
F3	0.41	4.07	0.59	0.18	0.56	16.82	0.51	0.27	0.11	0.52	0.16
F4	0.87	6.69	0.95	0.22	0.96	25.03	0.90	0.32	0.19	0.94	0.22
F5	0.82	6.55	0.95	0.13	0.93	25.15	0.86	0.32	0.17	0.95	0.27
F6	0.52	4.62	0.73	0.21	0.66	18.76	0.59	0.28	0.12	0.65	0.19
F7	0.90	7.34	0.93	0.22	0.96	27.11	0.91	0.33	0.22	0.91	0.23
F8	0.70	6.01	0.93	0.37	0.84	23.64	0.78	0.31	0.14	0.86	0.29
F9	0.45	5.15	0.66	0.25	0.60	21.33	0.58	0.31	0.14	0.58	0.22

: correlation coefficient, : release constant, and n: the release exponent.