Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Table 2

Main published works regarding biohybrid systems for sustained drug delivery, listed in terms of kind, activity, and encapsulation efficiency (EE%).

Biohybrid system	Therapeutic molecule	EE%	Ref.
NE-alginate/chitosan	Capsaicin	68.0%	[44]
Emulgel-jojoba oil/HPMC	Clotrimazole	—	[46]
Emulgel-xanthan gum	Acyclovir and ketoconazole	—	[47]
Emulgel-lecithin soy	Ketoprofen	—	[113]
Nanogel-agar	Sodium diclofenac	—	[48]
Emulgel-CMC	Sodium diclofenac	—	[114]
Emulgel-gelatin	Metronidazole	—	[45]
Poly(SMA)-neocarzinostatin	Neocarzinostatin	—	[115]
PEG-DNA	DNA	—	[52]
PEG-streptavidin	Streptavidin	—	[116]
PEG-L-asparaginase	L-Asparaginase	—	[53]
PEG-streptavidin	Streptavidin	—	[117]
PDMA-BSA	DNA	—	[57]
PMMA-BSA	Camptothecin	11.0%	[56]
ELP-FKBP	Rapamycin	—	[58]
Liposome-chitosan	Doxorubicin	98.0 %	[78]
Liposome-cellulose	Quercetin	40.0%	[77]
Liposome-cellulose	Rutin	58.0%	[77]
Liposome-gel	Lidocaine	21.6%	[118]
Liposome-gel	Bupivacaine	98.8%	[119]
Liposome-alginate	Benzocaine	63.2%	[120]
Liposome-PEG	Lidocaine	98.8%	[73]
Cyclodextrin/liposome	Quercetin	91.0%	[121]
Cyclodextrin/liposome	Tretinoin	88.7%	[122]
Cyclodextrin/liposome	Curcumin	50.0%	[123]
Cyclodextrin/PLGA	Oxaprozin	62.0%	[124]
SLN-PLGA-PEG-PLGA	2-Methoxyestradiol	91.3%	[125]
SLN-hydrogel	Natural resin	—	[93]
SLN-polycarbophil	Curcumin	88.1%	[86]
SLN-B12 vitamin	Insulin	55.9%	[85]
SLN-chitosan	Amphotericin B	88.5%	[126]
SLN-PLGA	Flurbiprofen	91.7%	[127]
SLN-dicetyl phosphate	Retinyl palmitate	99.1%	[128]
SLN-PEG	EGFP Plasmid	89.0%	[129]
SLN-PEG	Paclitaxel	11.0%	[130]
SLN-PEG	Salbutamol sulphate	30.0%	[131]
SLN-PEG	Noscapine	83.6%	[84]
SLN-chitosan	Carbamazepine	66.7%	[132]
SLN-chitosan	Ifosfamide	—	[89]
SLN-dextran	Ibuprofen	99.1%	[133]
SLN-chitosan	Tretinoin	99.6%	[134]
SLN-PLGA	DNA	93.1%	[135]
NLC-natural gum (D. regia)	Ondansetron	29.9%	[95]
NLC-PEG	Fluticasone propionate	97.0%	[94]
NLC-peptides	Docetaxel	77.5%	[136]
NLC-PEG	Biochanin A	99.0%	[137]
NLC-chitosan	Curcumin	96.6%	[138]
NLC-chitosan	Fubiprofen	97.5%	[139]
Lipospheres-β-CD	Butyl methoxydibenzoylmethane	85.0%	[106]
Lipospheres-β-CD	Rifampicin	—	[140]
Lipospheres-PLGA	Albumin	90.8%	[107]
Lipospheres-PLGA; Lipospheres-PEG	Donepezil hydrochloride; Ceftriaxone	—; 60.1%	[141]; [142]
Lipospheres-PEG	Gentamicin	85.0%	[143]
Lipid nanocapsules	Interleukin-15 (IL-15)	—	[109]
Lipid nanocapsules	Erlotinib	90.0%	[110]
Lipid nanocapsules	Doxorubicin	90.0%	[111]
Lipid nanocapsules	Quercetin	92.0%	[112]