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International Journal of Polymer Science
Volume 2017, Article ID 2581767, 10 pages
Research Article

Optimizing Delivery Characteristics of Curcumin as a Model Drug via Tailoring Mean Diameter Ranges of Cellulose Beads

Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

Correspondence should be addressed to Suh Cem Pang; moc.liamg@mechus

Received 29 May 2017; Accepted 16 August 2017; Published 26 September 2017

Academic Editor: Arthur J. Ragauskas

Copyright © 2017 Lee Ken Voon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Spherical cellulose beads with tailored mean diameter between micrometer (20–80 μm) and nanometer (40–200 nm) ranges were fabricated from regenerated cellulose of paper wastes via water-in-oil (W/O) microemulsion and nanoprecipitation processes, respectively. The mean diameter ranges of cellulose beads were precisely controlled via modulating fabrication parameters such as stirring speed, surfactant concentration, cellulose concentration, and reaction temperature. By tailoring their mean diameter ranges and using curcumin as a model drug, cellulose beads with enhanced loading capacities and optimized release kinetic profiles of curcumin were fabricated.