International Journal of Polymer Science / 2018 / Article / Tab 3 / Research Article
Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan Table 3 Changes in organoleptic properties, clotrimazole content, and drug particle size in hydrogels with unmodified CS (F1, F2) or with bGP-crosslinked CS (F3, F4) upon storage compared to values obtained to freshly prepared formulations.
Storage time (months) Parameter Hydrogel with Unmodified CS bGP-crosslinked CS F1 F2 F3 F4 0 pH 4.06 ± 0.02 4.08 ± 0.01 4.54 ± 0.04 4.56 ± 0.03 Particle size range (μ m) 6.0–49.5 6.0–47.0 4.0–40.0 4.0–41.5 Drug content (%) 95.6 ± 4.9 98.2 ± 3.5 97.3 ± 4.1 97.4 ± 3.3 25°C/60% RH 1 pH 4.16 ± 0.05 4.23 ± 0.05 4.51 ± 0.04 4.53 ± 0.02 Particle size range (μ m) 7.5–52.5 7.5–57.0 6.0–29.5 5.0–48.5 Drug content (%) 94.8 ± 3.3 96.1 ± 4.2 96.5 ± 3.5 97.1 ± 3.9 3 pH 4.40 ± 0.02 4.38 ± 0.03 4.35 ± 0.02 4.27 ± 0.03 Particle size range (μ m) 7.0–58.0 6.0–54.5 4.0–41.0 4.0–34.5 Drug content (%) 94.6 ± 5.9 92.4 ± 5.1 98.1 ± 4.1 95.2 ± 4.5 6 pH 4.31 ± 0.02 4.39 ± 0.01 4.26 ± 0.02 4.23 ± 0.02 Particle size range (μ m) n.d. n.d. Sedimentation Sedimentation Drug content (%) n.d. n.d. n.d. n.d. 40°C/75% RH 1 pH 4.20 ± 0.03 4.24 ± 0.05 4.56 ± 0.04 4.51 ± 0.02 Particle size diameter (μ m) Sedimentation Sedimentation 10.0–53.0 5.0–61.0 Drug content (%) n.d. n.d. 96.5 ± 3.5 97.1 ± 3.9 3 pH 4.40 ± 0.02 4.48 ± 0.02 4.36 ± 0.01 4.29 ± 0.03 Particle size range (μ m) n.d. n.d. 5.0–44.5 4.5–37.0 Drug content (%) n.d. n.d. 93.1 ± 7.1 94.2 ± 6.8 4 ± 2°C 1 pH 4.10 ± 0.05 4.03 ± 0.05 4.56 ± 0.04 4.53 ± 0.02 Particle size range (μ m) 12.0–58.5 7.5–65.0 8.0–59.0 10.5–45.0 Drug content (%) 94.3 ± 3.8 96.1 ± 4.2 96.5 ± 3.5 97.1 ± 3.9 3 pH 4.10 ± 0.02 4.12 ± 0.02 4.31 ± 0.02 4.37 ± 0.03 Particle size range (μ m) Sedimentation 6.0–59.5 11.0–40.0 5.0–45.5 Drug content (%) n.d. 95.1 ± 8.4 98.1 ± 4.7 95.2 ± 4.5 6 pH 4.23 ± 0.03 4.29 ± 0.03 4.28 ± 0.03 4.37 ± 0.01 Particle size range (μ m) n.d. n.d. 6.5–46.0 5.0–40.0 Drug content (%) n.d. n.d. 94.1 ± 4.9 96.0 ± 3.7
, mean ± SD; n.d.: not determined.