International Journal of Polymer Science / 2018 / Article / Tab 2

Review Article

Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Table 2

Summary of the main advantages and disadvantages of spectroscopic techniques.

TechniqueUseAdvantagesDisadvantagesReferences

Fourier transformed infrared (FTIR)Chemical compositionFast and inexpensiveComplicated sample preparationAlben and Fiamingo [27]
Pretsch 2003
Sapsford et al. [9]
Lin et al. [5]
Characteristic of each materialInterference of water
Possible quantificationRelatively low sensitivity
Requires dried samples
Destructive

UV-VisQuantification of concentrationCost effectiveInterference between materialsSapsford et al. [9]
Lin et al. 2014 [5]
Size and shape determinationSimple and fast
Useful for a variety of compounds

FluorimetryQuantitative fluorescence determinationHigh sensitivity Compound specificityLimited to fluorescent compoundsLakowicz [28]
Limited fluorescence lifetime

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