International Journal of Polymer Science / 2018 / Article / Tab 4

Review Article

Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Table 4

Summary of the main advantages and disadvantages of the described purification techniques.

TechniqueUseAdvantagesDisadvantagesReferences

FiltrationPurificationUseful for thermolabile compoundsTime consumingScopes [44]
Sterilization
ConcentrationRapid and simpleBigger sizes determined by the cut-off sizeSapsford et al. [9]
Dispersant changementCommercially available devicesSingle-use devicesRoy et al. [43]
Reduce size polydispersityCost effectiveDobrovolskaia and McNeil [42]

CentrifugationPurificationHigh efficiencySpecial equipment required for large volumesScopes [44]
ConcentrationRapid, facile, and economicDifficult to resuspend soft matterSapsford et al. [9]
Dispersant changementLow amounts of sample
 Appropriate for different kinds of nanomaterials

DialysisPurificationRapid, facile, and economicLimited to the membranes MWCOVauthier et al. [46]
ConcentrationCommercially available devicesHigh receptor solution volumesSapsford et al. [9]
Dispersant changementNo sample pretreatment

ElectrophoresisPurificationSimple and economicPostelectrophoresis purification stepsSapsford et al. [9]
Jason [51]
High resolution and sensitivity
Need of charged compoundsScopes [45]

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