Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone

Table 7

Kinetic parameters of the AMD release from the inclusion complexes and for the AMD dissolution in the two media.

Samples	pH	First step of kinetic release profile (0-50 min)				Second step of kinetic release profile (60-120 min)				Third step of kinetic release profile (120-300 min)
		AMD/HP-β-CD A	1.2	0.21	0.986	4.33	0.997	0.83	0.992	3.46	0.993	1.53	0.985	13.7	0.9885
AMD/HP-β-CD B		0.28	0.986	4.1	0.998	0.68	0.997	7.53	0.997	1.60	0.953	51.8	0.939
AMD/HP-β-CD C		0.18	0.934	3.66	0.993	0.95	0.990	1.82	0.988	1.54	0.995	2.4	0.998
AMD		0.05	0.954	2.55	0.999	—	—	—	—	—	—	—	—
AMD/HP-β-CD A	6.8	0.038	0.972	23.8	0.999	0.25	0.989	10.56	0.989	0.98	0.929	3.2	0.938
AMD/HP-β-CD B		0.041	0.867	25.79	0.998	0.22	0.972	12.85	0.971	1.00	0.941	4.2	0.950
AMD/HP-β-CD C		0.038	0.993	21.72	0.999	0.26	0.967	9.36	0.966	0.93	0.971	2.8	0.976
AMD		0.024	0.842	4.55	0.999	—	—	—	—	—	—	—	—

: diffusional exponent that characterizes the drug release mechanism; : release kinetic constant; and : correlation coefficients.