Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting

Table 7

Effect of different contents of AA on the drug release mechanism of Poly (CMCS-g-AA) hydrogels in solutions of different pH values using EGDMA as crosslinking agent (0.7% of AA).

Samples code	AA contents	pH	Release exponent ()		Order of release
HS1	25.45	1.2	0.728	0.995	Non-Fickian
		5.5	0.937	0.997	Non-Fickian
		7.5	0.912	0.992	Non-Fickian
HS2	32.72	1.2	0.746	0.994	Non-Fickian
		5.5	0.953	0.991	Non-Fickian
		7.5	0.936	0.983	Non-Fickian
SH3	40	1.2	0.733	0.989	Non-Fickian
		5.5	0.897	0.973	Non-Fickian
		7.5	0.817	0.972	Non-Fickian