Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting

Table 8

Effect of degree of crosslinking on the drug release mechanism of Poly (CMCS-g-AA) hydrogels in solutions of different pH.

Samples code	EGDMA contents	pH	Release exponent ()		Order of release
HS7	0.25%	1.2	0.712	0.990	Non-Fickian
		5.5	0.867	0.981	Non-Fickian
		7.5	0.795	0.979	Non-Fickian
HS8	0.50%	1.2	0.697	0.996	Non-Fickian
		5.5	0.846	0.998	Non-Fickian
		7.5	0.796	0.972	Non-Fickian
HS9	1%	1.2	0.710	0.981	Non-Fickian
		5.5	0.850	0.968	Non-Fickian
		7.5	0.798	0.988	Non-Fickian