Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

Table 2

Kinetic parameters (, , , and ) of various models for the release of 5-FU from the drug-loaded HAp-GEL polymer composites.

Release temperature	Composites	Zero order		First order		Higuchi
		32°C	HAp-GEL, 2% GA	0.134	0.674	0.310	0.279	41.20	0.817
37°C	0.220	0.837		0.280	0.331	11.60	0.955
42°C	0.120	0.831		0.150	0.299	6.50	0.891
32°C	HAp-GEL, 5% GA	0.125	0.825	0.300	0.824	40.60	0.934
37°C		0.200	0.569	0.240	0.297	10.50	0.747
42°C		0.101	0.762	0.130	0.243	6.01	0.905