International Journal of Rheumatology / 2009 / Article / Tab 1

Clinical Study

Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis

Table 1

Levels of hyaluronic acid (HA), matrix metalloproteases (MMP-1, MMP-3, and MMP-13), tissue inhibitors of metalloproteases (TIMP-1 and TIMP-2), platelet-derived growth factor (PDGF-AB), transformed growth factor (TGF-beta), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and insulin-like growth factor (IGF-I) were measured on knee synovial fluid and in platelet-rich plasma (PRP) releasate at a single point in time. Results are shown as mean SD, (median), and range (ng-pg/mL). ND not detected. -13 was measurable only in 13 of the 63 patients.

PRGFSynovial fluid

Leukocyte countND 400/ L
Platelet (x ) /mL ND
(356)
PDGF-AB (ng/mL) ND
(14.19)
TGF-beta1 (ng/mL)
(24.75) (0.62)
VEGF (pg/mL)
(169) (857)
HGF (pg/mL)
(413) (592)
IGF-I (ng/mL)
(53.4) (53.0)
HA ( g/mL)
(50) (1385)
TIMP-1 (ng/mL)
(46.0) (720.0)
TIMP-2 (ng/mL)
(59.0) (117.0)
MMP-1 (ng/mL)
(2.45) (13.0)
MMP-3 (ng/mL)
(6.43) (466)
MMP- (ng/mL)ND
(0.054)