Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis

Table 2

Principal component analysis coefficients of independent molecular marker factors in plasma from 63 patients with knee OA. Molecular markers were grouped into factors of related measures by principal component analysis using a Varimax rotation with Kaiser Normalization. Components with Eigen values >1 were extracted. Primary components of each factor are shown in bold type.

Biomarker	Factor
	1	2	3	4
Platelet count	0.846	−0.255	0.106	0.061
PDGF-AB	0.841	0.183	−0.186	0.177
TGF-beta1	0.853	−0.294	0.024	0.164
VEGF	0.599	0.381	0.354	−0.069
HGF	0.293	0.356	−0.489	0.505
MMP-1	0.112	−0.011	0.685	0.091
TIMP-2	−0.037	−0.014	0.828	0.213
MMP-3	−0.025	−0.058	0.138	0.832
TIMP-1	0.318	0.127	0.246	0.726
IGF-I	0.020	-0.821	0.054	0.044
HA	−0.131	0.774	−0.004	0.137