An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results
Box 1
Proposed characteristics of SRC.
Hypertensive SRC:
Systolic blood pressure 140 mmHg
Diastolic blood pressure 90 mmHg
Rise in systolic blood pressure 30 mmHg compared to baseline
Rise in diastolic blood pressure 20 mmHg compared to baseline
AND
One of the following features:
(a) Increase in serum creatinine 50% over baseline OR serum creatinine 120% of upper limit of normal for local laboratory,
(b) Proteinuria: 2+ by dipstick and confirmed by protein:creatinine ratio upper limits of normal (ULN),
(c) Hematuria: 2+ by dipstick or 10 RBCs/HPF (without menstruation),
(d) Thrombocytopenia: 100,000 plts/mm3,
(e) Hemolysis: by blood smear or increased reticulocyte count,
(f) Hypertensive encephalopathy.
Normotensive SRC:
Increase in serum creatinine 50% over baseline OR serum creatinine 120% of upper limit of normal for local laboratory
AND
One of the following features:
(a) Proteinuria: 2+ by dipstick and confirmed by protein:creatinine ratio upper limits of normal (ULN),
(b) Hematuria: 2+ by dipstick or 10 RBCs/HPF (without menstruation),
(c) Thrombocytopenia: 100,000 plts/mm3,
(d) Hemolysis: by blood smear or increased reticulocyte count,
