An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results
Table 3
Signs and symptoms of SRC.
Patients with hypertensive SRC (N = 66)
(%)
Systolic blood pressure >140 mmHg
64 (97)
Diastolic blood pressure > 90 mmHg
54 (82)
Rise in systolic blood pressure >30 mmHg compared to baseline
46 (70)
Rise in diastolic blood pressure >20 mmHg compared to baseline
37 (56)
Increase in serum creatinine >50 % above baseline OR serum creatinine > 120% of upper limit of normal for local laboratory
60 (91)
Proteinuria: >2+ by dipstick and confirmed by protein:creatinine ratio > upper limits of normal
25 (38)
Hematuria: >2+ by dipstick or >10 RBCs/HPF (without menstruation)
18 (27)
Thrombocytopenia: < 100,000 platelets/
20 (30)
Hemolysis: by blood smear or increased reticulocyte count
27 (41)
Hypertensive encephalopathy
9 (14)
Patients with normotensive SRC (N = 10)
(%)
Systolic blood pressure >140 mmHg
2 (20)
Diastolic blood pressure >90 mmHg
2 (20)
Rise in systolic blood pressure >30 mmHg compared to baseline
3 (30)
Rise in diastolic blood pressure >20 mmHg compared to baseline
2 (20)
Increase in serum creatinine >50% above baseline OR serum creatinine > 120% of upper limit of normal for local laboratory
9 (90)
Proteinuria: >2+ by dipstick and confirmed by protein:creatinine ratio > upper limits of normal
5 (50)
Hematuria: >2+ by dipstick or >10 RBCs/HPF (without menstruation)
4 (40)
Thrombocytopenia: <100,000 platelets/
2 (20)
Hemolysis: by blood smear or increased reticulocyte count
