Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules

Figure 3

Schematic outline of a hypothetical model of HLA-B27-induced inflammatory arthritis by misfolding and/or dimerisation. HLA-B27 matures slowly resulting in enhanced formation of aggregate structures, which can potentially induce ER stress responses and activate proinflammatory cytokine production. ER stress can be perpetuated by further proinflammatory cytokine production, and this can lead to the development of inflammatory arthritis.