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International Journal of Rheumatology
Volume 2011, Article ID 495792, 13 pages
http://dx.doi.org/10.1155/2011/495792
Review Article

Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis

1Centre LOEX de l'Université Laval, Génie Tissulaire et Régénération, LOEX-Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Quebec City, QC, Canada G1J 1Z4
2Département de Chirurgie, Faculté de Médecine, Université Laval, Quebec City, QC, Canada G1V 0A6

Received 1 June 2011; Revised 6 July 2011; Accepted 6 July 2011

Academic Editor: Eswar Krishnan

Copyright © 2011 Stéphane Chabaud and Véronique J. Moulin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose of this paper is to gather new findings in apoptosis related to SSc, to highlight relations between apoptosis and fibrosis, and to identify new therapeutic targets.