Clinical Study

Pathologies Associated with Serum IgG4 Elevation

Table 3

Pathologies (excepted IgG4-RD organ involvements) associated to serum IgG4 elevation in medical literature.

Number of cases and references

CancerPancreatic adenocarcinoma13 cases [18], 5 cases [19], 1 case [20], 8 cases [16, 17], 2 cases [1], 11 cases [21], 1 case [22]
Bile duct cancer/cholangiocarcinoma3 cases [16, 17], 4 cases [22], 17 + 20 cases [23]
Intraductal papillary mucinous neoplasm1 case [16, 17]

Autoimmune diseasesSystemic lupus erythematosus1 case [11], 2 cases [16, 17], 4 cases [our study], 1 case [24]
Antiphospholipid syndrome1 case [11], 2 cases [our study]
Autoimmune hepatitis1 case [16, 17]
Rheumatoid arthritis5 cases [11], 2 cases [25]
Systemic sclerosis3 cases [11], 1 case [our study]
Sjögren’s syndrome3 cases [11], 2 patients [our study]
Polymyositis/dermatomyositis1 case [11]

ANCA-related vasculitisChurg-Strauss syndrome * 4 cases [11], 4 cases [14]
Microscopic polyangiitis1 case [11], 1 case [our study]
Nonspecified1 case [16, 17]

InfectionsParasitic infections2 cases [our study], specific IgG4 antibody elevation [3, 2629]
Bacterial infections10 cases [our study]
Viral infections3 cases [our study]

OthersMulticentric Castleman’s disease * 7 cases [11], 1 case [30], 1 case [16], 1 case [31], 5 cases [12]
Eosinophilic disorders (fasciitis, pneumonia, and hypereosinophilic syndrome)1 case each (fasciitis and pneumonia) [11],
2 cases of hypereosinophilic syndrome [16, 17]
Chronic hepatitis1 case [11], 2 cases (auto-immune) [32]
Liver cirrhosis2 cases [11], frequent cause of serum IgG4 elevation [33]
Bronchial asthma1 case [11], 3 cases [34]
Idiopathic pulmonary fibrosis/interstitial pneumonia1 case [11], 4 cases [16, 17], 3 cases [our study]
Primary sclerosing cholangitis1 case [16, 17], 3 cases [35], 12 cases [36], 33 cases [37]
Chronic and idiopathic/acute pancreatitis1 and 2 cases, respectively [16, 17], 4 and 5 cases, respectively [18]
Behcet’s disease1 case [16, 17]
Cystic fibrosis7 cases [38], 2 cases [our study]

Pathologies in bold with * represent pathologies with especially frequent and high serum IgG4 elevation.