Autoantigen TRIM21/Ro52 as a Possible Target for Treatment of Systemic Lupus Erythematosus

Table 2

TRIM21-binding proteins.

Protein	Molecular function of TRIM21	Functional output	Reference
	(1) Substrate of TRIM21 E3 ligase
IRF3	Proteasomal degradation	Suppressing IFN-β production	[68]
IRF7	Proteasomal degradation	Suppressing IFN-α production	[70]
IRF8	Transcriptional activation	Promoting IL-12p40 production	[41]
IgG	Proteasomal degradation	Neutralization of IgG-coated virion	[82]
IKKβ	Translocation to autophagosomes	Suppressing NF-κB signaling	[91]
UnpEL	Unknown	Unknown	[39]
TRIM5α	Translocation to cytoplasm	Unknown	[111]
	(2) Proteins supporting TRIM21 E3 activity
Skp2	Facilitating p27 degradation	Promoting S-phase progression	[38]
Skp1	Facilitating p27 degradation	Promoting S-phase progression	[38]
Cul1	Facilitating p27 degradation	Promoting S-phase progression	[38]
βTrCP2	Unknown	Unknown	[38]
p62	Facilitating IRF8 degradation	Suppressing IL-12p40 production	[67]
TRIB2	Facilitating C/EBPα degradation	Promoting lung tumorigenesis	[85]
FADD	Facilitating IRF7 degradation	Suppressing IFN-α production	[71]
	(3) Proteins irrelevant to TRIM21 E3 activity
IRF3	Stabilization	Promoting IFN-β production	[69]
Daxx	Unknown	Unknown	[84]
Flash	Translocating Daxx to cytoplasm	Unknown	[84]
DCP2	Facilitating decapping activity	Unknown	[86]