The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

Table 2

Association of IL-12b SNP rs6887695 with clinical symptoms in SLE patients*.

		Genotype frequency, no. (%)				Allele frequency, no. (%)
SNP,; population	No. of subjects	Major homozygote	Hetero-zygote	Minor homozygote	P	Major allele	Minor allele	P	OR (95% CI)
Genotype; or allele		GG	GC	CC		G	C
Total cases	297	107	153	37		367	227
Rash
Positive	161	59	83	19	0.923	201	121	0.728	0.94 (0.68–1.31)
Negative	136	48	70	18		166	106
Photosensitivity
Positive	90	32	47	11	0.987	111	69	0.969	1.01 (0.70–1.44)
Negative	207	75	106	26		256	158
Arthritis
Positive	181	74	90	17	0.033	238	124	0.013	0.65 (0.47–0.92)
Negative	116	33	63	20		129	103
Oral ulcer
Positive	74	27	39	8	0.884	93	55	0.761	0.94 (0.64–1.38)
Negative	223	80	114	29		274	172

*SNP: single-nucleotide polymorphism; SLE: systemic lupus erythematosus; OR: odds ratios; 95% CI: 95% confidence interval.