|
Authors | Date |
Population/region |
Design | Disease group | Number of subjects | Polymorphisms | Findings |
|
Höhler et al. | 1997 | Caucasian/Germany | Case control | Juvenile onset Psoriasis (no. 60) | | −238 | Significant association |
Psoriatic arthritis (no. 62) |
122 | −308 | No association |
|
Date et al. | 1999 | Japan | Case control | Systemic arthritis (no. 50) | | −1031C/T | −1031C, −863A, −857T are significantly higher in case patients particularly in systemic group |
Pauciarthritis (no. 29) | 111 | −863A/C |
Polyarthritis (no. 32) | | −857T/C |
|
Ozen et al. | 2002 | Turkey | Case control | Systemic (no. 9) | | | −308A is associated with a poor prognosis |
Polyarthritis (no. 20) | |
−308G/A |
Persistent oligoarthritis (no. 15) |
51 | | |
Extended oligoarthritis (no. 7) | |
−238G/A |
No association |
Czech Republic | Case control | Systemic (no. 13) | | | |
Polyarthritis (no. 41) | | | |
Persistent oligoarthritis (no. 27) | 159 |
−308G/A, −238G/A | No association |
Extended oligoarthritis (no. 19) | | | |
Enthesitis-arthritis (no. 59) | | | |
|
| | | | | |
−308G/A | −308A is significantly associated with juvenile oligoarthritis |
Zeggini et al. | 2004 | Caucasian/UK | Case control | Persistent oligoarthritis (no. 92) Extended oligoarthritis (no. 52) | 144 simplex families |
−238G/A G/A G/A | −238G, +489A, +851A are significantly associated with persistent oligoarthritis |
| | | | | | ,
| No association |
|
Miterski et al. | 2004 | Caucasian/Germany | Case control | JIA | Up to 200 |
−238A/G, −308A/G, −857C/T | No association |
|
Modesto et al. | 2005 | Caucasian/Spain | Case control | Oligoarthritis (no. 29) Systemic arthritis (no. 26) | 55 | 308, −238, −376, −163G/A | No significant association, but −308A is more frequent in systemic group |
|
Jimenez-Morales et al. | 2009 | Mexico | Case control | JIA | 171 |
−308G/A −238G/A | −308A is significantly associated with JIA No association |
| | | | Systemic (no. 35) | | | The T allele demonstrated a significant protective effect against JIA in all groups |
| | | | Polyarthritis (no. 131) | | |
| | | | Oligoarthritis (no. 198) | 433 | TNFAIP3/rs10499194 |
| | | | Enthesitis-arthritis (no. 37) | | |
| | | | Other (no. 32) | | |
Prahalad et al. |
2009 |
Caucasian/Utah |
Case control | Systemic (no. 36) | | | The A allele conferred higher risk for JIA |
| | | | Polyarthritis (no. 133) | | |
| | | | Oligoarthritis (no. 199) | 441 | TNFAIP3/rs6920220 |
| | | | Enthesitis-arthritis (no. 40) | | |
| | | | Other (no. 33) | | |
|
Mourao et al. | 2009 | Portugal | Case control | Systemic (no. 8) | | | The −308GA/AA allele is related to higher disease activity |
Polyarthritis (no. 27) | | |
Oligoarthritis (no. 65) | 114 |
−308G/A |
Enthesitis-arthritis (no. 9) | | |
Psoriatic arthritis (no. 5) | | |
|