Review Article

TNF-α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications?

Table 1

TNF-α SNPs and JIA pathogenesis.

AuthorsDate Population/region DesignDisease groupNumber of subjectsPolymorphismsFindings

Höhler et al.1997Caucasian/GermanyCase controlJuvenile onset Psoriasis (no. 60)−238Significant association
Psoriatic arthritis (no. 62) 122−308No association

Date et al.1999JapanCase controlSystemic arthritis (no. 50)−1031C/T−1031C, −863A, −857T are significantly higher in case patients particularly in systemic group
Pauciarthritis (no. 29)111−863A/C
Polyarthritis (no. 32)−857T/C

Ozen et al.2002Turkey Case controlSystemic (no. 9)−308A is associated with a
poor prognosis
Polyarthritis (no. 20) −308G/A
Persistent oligoarthritis (no. 15) 51
Extended oligoarthritis (no. 7) −238G/A No association
Czech RepublicCase controlSystemic (no. 13)
Polyarthritis (no. 41)
Persistent oligoarthritis (no. 27)159 −308G/A, −238G/ANo association
Extended oligoarthritis (no. 19)
Enthesitis-arthritis (no. 59)

−308G/A−308A is significantly associated with juvenile oligoarthritis
Zeggini et al.2004Caucasian/UKCase controlPersistent oligoarthritis (no. 92)
Extended oligoarthritis (no. 52)
144 simplex families −238G/A
G/A
G/A
−238G, +489A, +851A are significantly associated with persistent oligoarthritis
, No association

Miterski et al.2004Caucasian/GermanyCase controlJIAUp to 200 −238A/G, −308A/G, −857C/TNo association

Modesto et al.2005Caucasian/SpainCase controlOligoarthritis (no. 29)
Systemic arthritis (no. 26)
55308, −238, −376, −163G/ANo significant association, but −308A is more frequent in systemic group

Jimenez-Morales
et al.
2009MexicoCase controlJIA171 −308G/A
−238G/A
−308A is significantly associated with JIA
No association
Systemic (no. 35) The T allele demonstrated a significant protective effect against JIA in all groups
Polyarthritis (no. 131)
Oligoarthritis (no. 198)433TNFAIP3/rs10499194
Enthesitis-arthritis (no. 37)
Other (no. 32)
Prahalad et al. 2009 Caucasian/Utah Case controlSystemic (no. 36) The A allele conferred higher risk for JIA
Polyarthritis (no. 133)
Oligoarthritis (no. 199)441TNFAIP3/rs6920220
Enthesitis-arthritis (no. 40)
Other (no. 33)

Mourao et al.2009PortugalCase controlSystemic (no. 8) The −308GA/AA allele is related to higher disease activity
Polyarthritis (no. 27)
Oligoarthritis (no. 65)114 −308G/A
Enthesitis-arthritis (no. 9)
Psoriatic arthritis (no. 5)